DBD Search
Grant R. Zimmermann
Managing Director of Business Development, Blavatnik Biomedical Accelerator
Displaying: 51 - 60 of 68 Results
Research Tool
Caspase 2 Knock Out Mice
Mice homozygous for this caspase-2 targeted mutation are viable and fertile. As the mutation deletes the QACRG active site and the caspase-2S sequence of the endogenous enzyme, this deletion was shown to inactivate both the long and short form of…
Investigators
- Junying Yuan
Research Tool
Ppp3ca Knock Out Mice
Ppp3ca (protein phosphatase 3, catalytic subunit, alpha isoform) is a calcium- and calmodulin-dependent serine/threonine protein phosphatase. It is an important signaling molecule in T cells, neurons, the heart, and kidneys. The catalytic domain of…
Research Tool
ROSA26::FLPe Knock In Mice
Homozygous FLPeR mice are viable and fertile, with widespread expression of the FLPe variant of the Saccharomyces cerevisiae FLP1 recombinase gene driven by the Gt(ROSA)26Sor promoter. The FLPe recombinase variant exhibits enhanced thermostability…
Investigators
- Susan M. Dymecki
Research Tool
Chx10-EGFP/cre,-ALPP Transgenic Mice
Mice hemizygous for the transgenic insert are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. The transgene insert contains a fusion product involving Cre recombinase and an Enhanced Green…
Investigators
- Connie Cepko
Research Tool
tetO-Gata6 Transgenic Mice
Gata6 Tg mice express GATA binding protein 6 (Gata6) cDNA under control of a tetracycline operator (tetO). Hemizygotes are viable and fertile. GATA6 is a zinc-finger-containing transcription factor involved in the regulation of early axial…
Research Tool
ROSA26::FLPe knock-in Targeted Mutation
Mice homozygous for the R26Fki knock-in allele (FLPeR mice) are viable and fertile, with widespread expression of the FLPe variant of the Saccharomyces cerevisiae FLP1 recombinase gene driven by the Gt(ROSA)26Sor promoter. The FLPe recombinase…
Investigators
- Susan M. Dymecki
Research Tool
Crx GFPAP Transgenic Mice
Hemizygotes are viable and fertile. Expression of human placental alkaline phosphatase (PLAP) and GFP recapitulates that of the endogenous Crx promoter in the retina at embryonic time points as early as embryonic day 12.5 (E12.5) and in the retina…
Investigators
- Connie Cepko
Research Tool
casp-11 Knock Out Mice
Caspase 4 (also known as caspase 11) is a critical upstream regulator in the caspase cascade with an important dual role in regulating both inflammatory response and apoptosis. Splenocytes harvested from homozygous mice both before and after…
Investigators
- Junying Yuan
Research Tool
Shh (EGFP/cre) Transgenic Mice
This strain expresses a fusion product involving Enhanced Green Fluorescent Protein (EGFP) and Cre recombinase from the endogenous Shh locus. EGFP and cre expression are consistent with the endogenous gene. Fluorescence is detected in the distal…
Research Tool
Crx Knock Out Mice
Homozygotes are viable and fertile and do not display any gross physical abnormalities. These mice do not elaborate photoreceptor outer segments and synaptic termini, and they lack cone and rod activities as assayed by electroretinograms. Circadian…
Investigators
- Connie Cepko