DBD Search
Grant R. Zimmermann
Managing Director of Business Development, Blavatnik Biomedical Accelerator
Displaying: 31 - 40 of 68 Results
Invention
The next generation of cholesterol screening - A personalized diagnostic index for the improved assessment of cardiovascular risk using a novel method for the measurement of lipoprotein subtypes
OpportunityThis program offers the next generation of cholesterol screening. In 2013, 96 million visits to doctors' offices in the US included a cholesterol test.Problem/Unmet needCurrent practice of measuring total HDL level in serum does not…
Investigators
- Frank Sacks
Invention
Metabolic labeling and direct imaging of choline-containing phospholipids in vivo
A functional analog of a metabolic phospholipid precursor has been devised that, when contacted with cells, becomes incorporated into a cells endogenous phospholipids through cellular metabolic processes. The resulting phospholipids contain a moiety…
Investigators
- Adrian Salic
Invention
Gluconeogenesis as a pro-survival treatment for neurons under stress
A series of AAV-based gene therapy approaches to reprogram certain metabolic enzymes in rod and cone cells in the eye to promote survival in degenerative conditions such as retinitis pigmentosa. Additionally, an independent series of such vectors…
Investigators
- Constance L. Cepko
- Claudio Punzo
Invention
anti-MARCO monoclonal antibody
The monoclonal antibody recognizes the Macrophage Receptor with Collagenous structure (MARCO). The scavenger receptors (SRs) expressed by macrophages are thought to play an important role in the immune response against bacteria by mediating binding…
Investigators
- Lester Kobzik
- Aiyappa M. Palecanda
Invention
Absolute quantification of Proteins (AQUA)
This invention provides methods, reagents and kits for obtaining absolute quantification of proteins and their modifications directly from cell lysates. In particular, the invention provides peptide internal standards for use in high performance…
Investigators
- Steven P. Gygi
- Scott A. Gerber
Invention
Knockout mouse model for human liver cancer
While most hepatocytes in healthy liver are resting cells, deletion of Mad2 in liver activates the cell cycles and causes proliferation of hepatocytes. Cre-mediated, simultaneous liver-specific knockout of Mad2 and p53 induces mouse cancer which…
Investigators
- Peter K. Sorger
- Ying Yue
Invention
Homozygous IKKepsilon knockout mouse as an animal model for influenza virus infection
Homozygous IKKepsilon (inhibitor of kappaB kinase epsilon) mutant mice are used as animal models for influenza virus infection. Homozygous deletion results in a complete loss of the endogenous kinase function in lung, spleen, and embryonic…
Investigators
- Thomas Maniatis
- Benjamin R. tenOever
Invention
Monoclonal IgE anti-ovalbumin antibody
A laboratory from the Harvard School of Public Health has developed a monoclonal Ig E mouse anti-ovalbumin. This antibody is useful as a positive control in ELISA assays used to measure the level of IgE anti-ovalbumin antibodies in mouse models of…
Investigators
- Lester Kobzik
- Aiyappa M. Palecanda
Invention
Protein-based therapies using quantitatively designed proteins
A bipartite, quantitatively designed protein having two discrete ligands and a linker; one ligand having the ability to strongly bind to a particular cell, the other having the ability to affect a target only when the previous ligand binds. For many…
Investigators
- Pamela A. Silver
- Pablo Cironi
- David G. Miguez
Investigators
- Christopher JL Murray
- Yidong Ding
- Caroline Cook Alter
- Prasanta Mahapatra